Rebellious
Diagram of neurotransmitter reuptake in synaptic space
Rehabilitation - a mechanism that reabsorbs neurotransmitters in the synaptic cleft through presynaptic neurons. This process is done using special transport proteins, called neurotransmitter transporters.
Rehabilitation allows the neurotransmitter to be reused by the neuron. In the case of noradrenaline 80% is retained and the remaining 20% is broken down by enzymes such as MAO and COMT, or diffused. Inhibition of re-uptake by blocking transporters results in an increase in neurotransmitter concentration and a stronger stimulation of appropriate receptors.
The reverse capture inhibit mechanism is used:
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