Team of Job

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The hyper-IgE syndrome (HIES, Job syndrome) - a rare syndrome of genetically impaired immunity, with autosomal dominant inheritance. It is believed that the syndrome is associated with impaired neutrophil chemotaxis caused by decreased production of interferon gamma. The Hiob syndrome is characterized by recurrent staphylococcal infections, dermatitis, severe pulmonary inflammation and elevated IgE levels in plasma. The disease causes mutations in the STAT3 gene at locus 4q21.

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