Waller's nephew

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Waller's degeneration in nerve fibers cut and crush, proximal and dist, 37 and 42 hours after injury. Yellow fluorescent dye (YFP) axons, computer image changed to readable (yellow color replaced green). 100 × magnification

Waller's degeneration (primary axonal degeneration) - a neuropathological change that occurs as a result of the breakdown of the nerve fibers. It is accompanied by nerve intersections, crushes, excessive stretching, nerve ischemia. The name commemorates the discoverer of the phenomenon, Augustus Waller, who described these changes in frogs with cut sublingual and lingual nerves in 1850.

Interruption of the nerve fibers causes changes in the axon and myelin sheath. Further, the cut off portion of the axon degenerates in the first place. Microscopically, cytoskeleton disintegration and organelle accumulation are observed. Then there are myelin sheath disorders: the so-called. Ischemic cells, ovaries, lipid deposits, macrophage infiltration. Empty, no-axons myelinated casings can survive up to 52 days. Bibliography

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