Volume of distribution

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Volume distribution - a pharmacokinetic parameter that characterizes drug distribution in the body. It is defined as the hypothetical volume of body fluids in which the drug, after an even distribution, would reach the same concentration as in the blood. Mathematically, the volume of distribution (Vd) is the proportionality factor between the quantity of drug in the body (A) and its concentration observed at the same time in blood (C) according to the equation: V d = A C {\displaystyle V_{d}={\frac {A}{C}}}

It is expressed in units of volume, and since for many drugs it exceeds the values ​​corresponding to the volume of body fluids, it is also referred to as so. The apparent volume of distribution.

The numerical value of this parameter gives an idea of ​​the distribution of the drug in the body, ie:

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