Repair by cutting the rules

-

BER scheme. The exact description in the text

Base excision repair (BER) - a DNA repair mechanism in cells designed to remove damage to individual DNA bases during DNA replication. Bug fixes are necessary to avoid introducing mutations during replication.

Single bases in DNA can be chemically modified, eg by deamination or alkylation, resulting in improper evaporation of the bases and consequently introduction of mutations in the DNA. Repair by cutting the rule involves cutting the mutated DNA helix principle and repairing it. Two types of enzymes, DNA glycosylase and AP endonuclease are involved in the process. DNA glycosylase crosses the β-N glycosidic bond between the damaged base and the deoxyribose molecule to form the apurinidic / apirimidine site. Endonuclease AP recognizes this site and cuts DNA 5 'from AP to form 3'-OH free end. The DNA polymerase, Pol I, extends the DNA strand from the 3'-OH free end using exonuclease activity to replace the damaged nucleotide and the next few. Then the new thread is linked to the old one by DNA ligation. There are monofunctional glycosylases, and bifunctional glycosylases - apart from cutting N-glycosidic bonds, they also have bile properties and remove APs by β-elimination, leaving a single nucleotide gap in DNA.

wiki

Comments

Post a Comment

Popular posts from this blog

Association of Jewish handicrafts "Jad Charuzim"

-
The Jewish Handgun Association "Jad Charuzim" - a Jewish craft organization, operating in Galicia since 1875. She was the founder of many synagogues (eg Yad Charuzim Synagogue in Sanok, Jad Charuzim Synagogue in Yaroslav, Zasany Synagogue in Przemysl), burs, self-help and charity activities, libraries, readings and readings. In 1927, in order to enable its members to use small loans, the association established its own credit cooperative "Cooperative Bank of Cooperatives". The Association's activities ceased during World War II. wiki
Read more

Grouping Red Arrows

-
Raggruppamento Frecce Rosse (Red Arrow Group) - Collaborative armed formation of an Italian army composed of Indians, Arabs and Africans during the Second World War. From May to July 1942, an armed formation was formed under the name Raggruppamento Centri Militari, consisting mainly of British Army prisoners of war originating in Arab countries, India and northern and eastern Africa. They were Hindus, Arabs, Sudanese, Tunisians. The officers and the non-commissioned officers were Italian. The formation consisted of three subdivisions: It was about 1.2 thousand. including about 400 Hindus and about 200 Arabs. Colonel Massimo Invrea de Stato headed it. Subsequently, a small number of Tunisians and Indians were sent to Italy to complete their parachute training in Tarquinia. In August 1942, the formation was renamed Raggruppamento Frecce Rosse. After the defeat of the German-Italian forces at El Alamein at the turn of October and November 1942, the Indians and Arabs lost motivation t...
Read more

Catechism of Polish Child

-
Catechism of the Polish Child - one of the patriotic poets Wladyslaw Belzy published in the volume of the Polish Children's Catechism in 1900. The poem is also known under the title "Confession of the Polish Child" or "Catechism of a Young Pole". It starts with the words "Who are you? "Little Pole". His simple form, referring to children's calculations, made him the simplest form of patriotic education of the youngest generation. The work consists of basic questions and answers about the identity features of a young Pole. It made it easier to memorize national characters and symbols. This work was covered in 1951 by censorship in Poland, subject to immediate withdrawal from libraries. wiki
Read more