Gyraza DNA

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Mechanism of action gyrase DNA

Gyraza DNA - an enzyme found in Procaryota (especially in bacteria), belonging to type II topoisomerases. Using energy derived from hydrolysis of ATP, it catalyzes the introduction of negative turns in the DNA helix.

Structure and meaning

The enzyme consists of two subunits A that bind covalently to the deoxyribose phosphate scaffold of the DNA and from the B subunit that provides energy to break down ATP. The activity of these subunits inhibits novobiocin.

Gyraza plays an important role in the process of replication, transcription and recombination. Inhibitory

Medications that inhibit bacterial gyrase A subunit to inhibit microbial proliferation are used. These drugs belong to the group of 4-quinolone derivatives (nalidixic acid and its derivatives as well as fluoroquinolones) and have a bactericidal effect.

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