Test Schillinga

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Schilling Test - A test to evaluate the absorption of vitamin B12 from the gastrointestinal tract based on urinary excretion. It is an indirect method of determining the presence of internal factor (IF) in gastric juice. The test consists of labeling What Vitamin B12 and determining the radioactivity of urine as a measure of excretion of the compound. The test is carried out in several phases. In the first phase, the patient must be fasted; after passing urine, p.o. (orally) vitamin B12 labeled Co at 1 μg, and after 2 hours i.m. (intramuscular) dose of 1000 μg vitamin alone. Radioactivity measurement is performed in the urine collected 24 hours after vitamin B12 administration. The standard is 10% of the oral dose of vitamin A in the urine, a value of 7% indicates a decrease in its absorption. In the second phase of the test, vitamin B12 is administered together with an internal factor (IF) to exclude malignant anemia.

The name of the study came from his inventor, Robert F. Schilling.

Today, the practice test is not being used due to the difficult availability of radiolabeled vitamin B12.

See terms related to medical terms and related wikipedia.

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