Transforming growth factor beta

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Transforming growth factor beta, TGF-β (transforming growth factor β) - a protein consisting of three isoforms: TGF-β1, TGF-β2, TGF-β3. It belongs to a larger family of proteins called the superfamily of transforming growth factor beta, which includes, inter alia, inhibin, activin, AMH, bone morphogenetic proteins. TGF-β controls the proliferation and differentiation of most cell types. It has an anti-inflammatory effect.

In simplified terms, the transforming growth factor beta manages cells during their development and contributes to wound healing. In the normal state TGF-β is captured by the fibrillin glycoprotein into the connective tissue. Marfana TGF-β is not bound by fibrillin and remains a free part of the blood, leading to abnormal cellular tissue behavior.

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