Complex attacking the membrane

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Cell death through MAC action

The membrane attack complex (MAC) is a protein structure formed at the final stage of complement activation. Participates in one of the important mechanisms of the non-specific immune response. As a result, lysis (death) of the cell occurs.

Typically, bacteria are created on the surface of pathogenic bacteria that enter the body, but can also arise independently and then combine with various complement inhibitors. It consists of 5 C5, C6, C7, C8 and C9 complement complement members which form a complex of the (C5b678) 1 (C9) n structure of the ring structure. The hydrophobic domains of the C8 and C9 components allow for the attachment of the complex to the cell membrane.

The homologous restriction factor (HRF, CD59) binding factor C8 and C9 inhibits the formation of MAC - it is its inhibitor. Formation of the membrane attacking complex

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