Mal de Meleda

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Mal de Meleda (endemic symmetric palm and posterior keratosis palmoplantaris transgradiens of Siemens) - a rare genodermatosis manifesting hyperkeratosis of the palm and soles of the palm and soles, described and most commonly found in the population of the Mljet Island (owned by Meleda) took a toponym to determine the disease. The disease is related to the mutation of both SLURP1 gene alleles in the 8qter locus; The examined patients were homozygous for the 82delT mutation. He described her as the first Dublin doctor, Luca Stulli. In the classification of skin diseases Behrenda from 1839 for the first time used the wrong name Mal de Melada (the name Melada refers to another island in the Adriatic, Molat). The name has sometimes been corrected; Occasionally, the second malformed form, Mal de Maleda. The largest series of cases (70) was presented by Franjo Kogoj in 1963.

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