No. 110913-773444

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Penicillamine (ATC M01CC) is an organic compound of the α-amino acid group, one of the penicillin metabolites. It has chelating properties, which is used in medicine. Produces stable, water-soluble complex binders with cations of copper, lead, mercury, cadmium, thallium, zinc, nickel, gold and iron. It can chelate the ions that form the metalloproteinases and thus reduce the activity of these enzymes. It has many side effects. Medical use only has D-penicillin because its enantiomer, L-penicillamine, is toxic (inhibits the action of pyridoxine).

Biological activity Distribution

The drug is absorbed well, reaches peak plasma concentration 2 hours after administration. 80% of the drug excreted in the faeces and urine within 48 hours after administration, trace amounts may be detected in plasma for several dozen days. indications Contraindications Side effects

Side effects are common and can be severe, sometimes even leading to death. Symptoms of lichen planus or lupus-like changes are common. A serious complication is penicillin induced myasthenia gravis (D-penicillamine induced myasthenia gravis). Pregnancy and lactation C. Do not use during pregnancy and breast-feeding. Wilson's disease in pregnant women; In this case, the dose should be reduced to 1 g / day. preparations Bibliography

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